It's hard to be a "small" manufacturer in just about anything not craft related - this curve has been going on for centuries, and is largely beneficial. For instance, a small maker of commercial jets would be a tough slog.
Pollution and efficiency are metrics which are mostly solved by big solutions.....sure, Ford is big, but selling millions of cleaner vehicles does a big cleanup.
I think everyone should cheer energy efficiency standards because this is what allows fuels to cost less - and/or allows the same work done for less fuel or money. That is, when there is less use, the stocks of fuel build up and the price stays better.
It's all win-win as long as the standards are phased in...as most have been. Look at the new stove standards - yes, they may be tough, but think about two things. First, some stoves from as early as 1990 or so met or almost met them (Encore). So here we are 24 years later and makers will STILL have 3-8 years to work their way into them. Vehicle standards...well, we certainly lagged behind the rest of the world for a couple decades on those! Europeans were getting the same mileage per liter as many of our cars were getting with a gallon! This did not happen by accident. Certain administrations decided to cater to a so-called "American Lifestyle" which was basically an entitlement to both cheap fuel and the "right" to spew as much pollution and use as much fuel as $$ could buy. That's not smart planning, IMHO, but it appeals to the public like candy does to a baby.
Many manufacturers like nothing more than improved efficiency. It helps them produce products for less money - that is, their machines get more and more efficient - and also allows them to rise above the competition by making a better (more efficient) product.