Deuce, is your home set up as two zones or is it just two furnaces tied together into one duct? If it were two separate zones (say upstairs and downstairs), I wouldn't change it as zoned heat is more economical and works better. If you have two furnaces tied together to make capacity, you might be able to replace them with one high efficiency furnace, especially if you have added insulation and other improvements. I would recommend doing a heat load calculation to see what your losses are and size accordingly.
Adding A/C to an older home can be difficult if the ductwork is less than ideal. Those high velocity systems are good for older homes if you have to snake ductwork down through a wall (thus the 2" duct size). The friction losses are higher and you need more fan horsepower to do it as well as all new (expensive) ductwork. Those 2" ducts are pretty pricey compared to conventional ductwork, but are a lot easier to install. If you have the room in the attic, you might consider a conventional heat pump with minimal electric heat for the second floor. The cold air tends to drift downstairs and cools the whole house on all but the hottest days and gives you a second zone of heat at the same time. Of course, if you can run the ductwork down through closets or box it in, it will work even better.
This approach may be overkill for NW PA, but it will work the best and cost the least to run. Our house here in MD was done with the old GE Airwall system in the basement that uses 4" ductwork to go up 2 1/2 stories. It ran continuously and the second floor never got really comfortable in hot weather. I put in a heat pump in the attic and never got around to hooking up the electric heat. We don't really miss the electric heat much. It does get a little chilly when the unit defrosts, but I hate the thought of using electric heat. I think it works very well in our situation.
Heat pumps are hard to get used to, especially if you are used to oil or gas heat or live up north. They are usually sized to handle the cooling load and will be undersized in cold weather. If you oversize the unit to cover the heating loss, the unit will not run long enough in the summer to dehumidify the house. They are not much more expensive to install compared to an A/C unit and can save you a lot of energy in the spring and fall. If you put in a conventional furnace and a heat pump, you will need what's called a fossil fuel kit. It's basically an outdoor thermostat that shuts off the heat pump when it gets colder out. Usually the stat is set at about 30 degrees as this is where the heat pump usually falls short and you start to need backup heat. I have mine set at apout 40 because the unit starts defrosting a lot between 30 and 40 degrees. You can adjust it later if you want.
The big name in high velocity systems is Unico, though I seem to recall another similar system.
http://unicosystem.com/ They are very highly engineered and need to be well thought out if they are going to work well. Shooting a hich velocity stream of cold air into a room is not without its problems, but they do dehumidify like nothing else out there. Sit down when you look at the quotation, though. Around here, they start at about $10k and go up, depending on the complexity of the install.
Hope this helps!
Chris